Questions? Feedback? powered by Olark live chat software
All Site

Products for Monitoring the Cytokine Storm Resulting from SARS-CoV-2 Infection

It has been reported that severe and critically ill patients with SARS-CoV-2 often have elevated inflammatory factors. Similarly, overactivation of the immune system during viral infections can lead to the excessive production of immune cells and inflammatory cytokines, a process commonly referred to as a cytokine storm.

Therefore, analysis of inflammatory factors in severe patients may be used to monitor disease progression, disease trends, evaluate prognosis, and guide therapy. Bio-Techne is the leader in this field. Our R&D Systems® brand antibodies and proteins are the core of every Bio-Techne immunoassay platform. Backed by over 68,000 citations and the expertise behind the gold-standard Quantikine® ELISAs, our immunoassays can be trusted to deliver reliable results the first time and every time.

Luminex toolkit for CRS & Other resources

High Performance Panel
Analytes

Human Cytokine Panel A

CCL2/MCP-1 • CCL3/MIP-1α • CCL4/MIP-1 β • CCL5/RANTES • CXCL5 ENA-78 • CXCL8/IL-8 • FGF basic •G-CSFGM-CSFIFN-γ • IL-1α/IL-1F1 • IL-1β/IL-1F2 • IL-1ra/IL-1F3 • IL-2 • IL-4 • IL-5 • IL-6 • IL-10 • IL-17 • TNF-α • Thrombopoietin/Tpo • VEGF

Human High Sensitivity Cytokine Panel A

CXCL8/IL-8 • GM-CSFIFN-γ • IL-1α/IL-1F2 • IL-2 • IL-4 • IL-5 • IL-6 • IL-10 • IL-12 p70 • TNF-α • VEGF

Human High Sensitivity Cytokine Panel B

GM-CSFIFN-γ • IL-1b/IL-1F2 • IL-2 • IL-5 • IL-6 • IL-7 • IL-13 • IL-15 • IL-17A • IL-17F • IL-22 • IL-23 • IL-31 •IL 33 • IL-36β • TNF-α

 Bold : CRS analyte

Luminex toolkit for CRS sales flyer but

Proteome Profiler™ Antibody Arrays:

Analyze the expression levels of up to 111 cytokines simultaneously, using only standard Western blotting equipment. Save time and discover novel responses with this unbiased approach.

> Arrays for CRS

Quantikine ELISA - Sensitivity and Accuracy:

> Cytokine Release Syndrome Quantikine® ELISAs

ELISpot Kits & FluoroSpot Kits:

> ELISpot kits available

 bio techne RnD Systems a bio techne brand NEW

Novus resources for COVID-19 research

Novus offers rabbit polyclonal antibodies to nsp5 (NBP1-78110) and nsp13 (nbp2-89168) proteins which are validated in several applications (e.g., WB, ICC/IF, ELISA). Novus innovator’s program allows you to test some of these available antibodies for the detection of SARS-CoV-2. Additionally, through Novus’ 100% guarantee you can test antibodies against SARS-CoV-2 targets sharing 90% or greater homology with proteins in SARS-CoV. 

find out more

Development of a Rhesus Macaque Model of COVID-19:

A recent study developed an animal model of SARS-CoV-2 infection in rhesus macaques and utilized the rabbit polyclonal anti SARS-CoV nucleocapsid antibody [NB100-56576] to successfully detect the presence of the SARS-CoV-2 virus in infected tissues.

novus dw nb antibodies sars cov2 nucleocapsid

Pathological changes in rhesus macaques infected with SARS-CoV-2. SARSCoV-2 nucleocapsid antigen is detected by immunohistochemistry in (g) type I pneumocytes, (j) type I pneumocytes (asterisk) and type II pneumocytes (arrow) as well as alveolar macrophages (arrowheads), (k) mediastinal lymph node, and (l) macrophages and lymphocytes in the lamina propria of the cecum. Magnification 400x. Modified from Figure 4: bioRxiv March 21, 2020 //doi.org/10.1101/2020.03.21.001628

novus

Custom Services

Molecule animation SMWe understand everyone’s research is unique. If you cannot find the immunoassay required for your research, or you need a customised RNAscope probes or you want to use an existing antibody for an untested application. Please contact our team at lifescience@invitro.com.au

Products for Immune Cell Isolation & Identification for Investigating SARS-CoV-2 Infection

Immune cell isolation and culture are necessary for both the basic research of immune cell functions during SARS-CoV-2 infection, as well as for expanding specific immune cell populations for therapeutic purposes. Bio-Techne is focused on providing the highest quality reagents for isolating, differentiating, and identifying immune cells.

R&D Systems® MagCellect Immune Cell Selection Kits

Product
Species
Catalog #

CD14+ Cell Isolation Kit

Human

MAGH105

CD45+ Cell Isolation Kit

Human

MAGH125

CD3+ T Cell Isolation Kit

Human

MAGH101

Naïve CD4+ T Cell Isolation Kit

Human

MAGH115

CD4+ T Cell Isolation Kit

Human

MAGH102

Memory CD4+ T Cell Isolation Kit

Human

MAGH116

Naïve CD8+ T Cell Isolation Kit

Mouse

MAGM207

CD8+ T Cell Isolation Kit

Human

MAGH112

Natural Killer Cell Isolation Kit

Human

MAGH109


> Learn more about the MagCellect Cell Selection Kits from R&D Systems.

R&D Systems® Kits for Immune Cell Differentiation or Expansion

Product
Species
Catalog #

CellXVivo Dendritic Cell Differentiation  Kit

Mouse

CDK008

CellXVivo M1 Macrophage Differentiation Kit

Human

CDK012

CellXVivo M2 Macrophage Differentiation Kit

Human

CDK013

CellXVivo Monocyte-derived DC Differentiation

Human

CDK004

Cloudz Natural Killer Cell Expansion Kit

Human

CLD004

CellXVivo Natural Killer Cell Expansion Kit

Human

CDK015

CellXVivo Th1 Cell Differentiation Kit

Mouse

CDK017


> Learn more about the CellXVivo  and Cloudz kits from R&D Systems.

SARS-CoV/CoV-2 Products

03232020 coronovirus brochure landing page img v4Since the S protein, ACE-2, and TMPRSS2 have important functions in SARS-CoV-2 replication, it is important to fully understand the role these proteins play in SARS-CoV-2 infection. Bio-Techne offers a variety of reagents to investigate the mechanisms of the SARS-CoV-2 life cycle.

See the complete list of products we have for researching the SARS-CoV-2 life cycle.

> Download our new Tools to Support Coronavirus Research brochure. 

 

RnD Systems a bio techne brand NEW

novus

 

Molecule
Brand
Catalog #
Species

SARS-CoV-2 Papain-like Protease

R&D Systems

E-611

Virus

 

Antibodies
Molecule
Brand
Catalog #
Species

SARS Spike Protein

Novus Biologicals

NBP2-24942

Virus

Novus Biologicals

NBP2-24808

Virus

Novus Biologicals

NB100-56578

Virus

SARS Nucleocapsid Protein

Novus Biologicals

NB100-56683

Virus

Novus Biologicals

NBP2-24745

Virus

SARS Envelope Protein

Novus Biologicals

NB100-56562

Virus


> View all SARS-CoV/CoV-2 products from Novus Biologicals.

ACE-2 Products

Recombinant Proteins
Molecule
Brand
Catalog #
Species

ACE-2

R&D Systems

933-ZN

Human

R&D Systems

3437-ZN

Mouse

 

Antibodies
Molecule
Brand
Catalog #
Species

ACE-2

Novus Biologicals

NBP2-67692

Human, Mouse, Rat

R&D Systems

AF933

Human

R&D Systems

AF3437

Mouse

 

ELISAs
Molecule
Brand
Catalog #
Species

ACE-2

Novus Biologicals

NBP2-66387

Human

Novus Biologicals

NBP2-78734

Human


> View all ACE-2 products from R&D Systems.
> View all ACE-2 products from Novus Biologicals.

TMPRSS2 Products

Recombinant Proteins
Brand
Catalog #
Species

Novus Biologicals

H00007113-Q01

Human

 

Antibodies
Brand
Catalog #
Species

Novus Biologicals

NBP1-20984

Human

 

Small Molecule Inhibitors
Product
Brand
Catalog #
 

Camostat mesylate

Tocris

3193

 

> View all TMPRSS2 products from Novus Biologicals.

New Publication alert

This publication cites R&D Systems Ace2 polyclonal antibody as showing the capacity to block Novel Coronavirus virus entry.  
> Read the publication now
> Find out more about the Ace2 polyclonal antibody

ACD Bio

RNA expression of IL6 gene in Human tissue using RNAscopePatients with severe COVID -19 infections suffer from acute respiratory distress syndrome (ARDS) which is induced by the release of cytokines such as IL-6, IL-1β, IL-10 and TNFα among others. RNAscope assays can identify the cells secreting these inflammatory cytokines.

Picture: RNA expression of IL6 gene in Human  tissue using RNAscope®

 

acd bio  find out more sales flyer but

Coronavirus Research Resources

Diagnosis and Disease monitoring NPTherapeutic Development NPDrug repurposing NPVaccine Development NP


Together, we can discover the tools needed to contain the spread of this pathogen.


Our Premium Brands for COVID-19 Research