Drug Repurposing
Developing new drugs that are safe and effective is both time-consuming and costly. However, repurposing existing drugs, also known as drug repositioning, is a strategy that may enable a more rapid response to infectious disease outbreaks.
These resources feature innovative Drug Repurposing tools for COVID-19 research.
The Tocriscreen Compound Library
The Tocriscreen Library of FDA-Approved Drugs (Tocris, Catalog # 7200) offers 190 FDA-approved compounds supplied pre-dissolved in DMSO. This library of compounds is ideal for screening assays for drug repurposing. Since the efficacy and safety of FDA approved drugs have been established, the amount of time required to bring a repurposed drug to the market may be dramatically reduced.
Libraries of bioactive compounds can also be screened with the aim of developing a novel therapeutic against COVID-19. Tocris offers a library of 1280 fully annotated compounds for screening and identifying compounds that could target SARS-CoV-2. The Tocriscreen 2.0 compound library, which has very little overlap with other libraries on the market, is available in 3 formats.
2.0 MICRO
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2.0 MINI
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2.0 MAX
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| #. of Compounds | 1280 | 1280 | 1280 |
| Volume | 15 μL | 50 μL | 250 μL |
| Solution Format | 10 mM DMSO | 10 mM DMSO | 10 mM DMSO |
| Seal | Peelable foil seal | SepraSeal Cap | SepraSeal Cap |
| Storage Format | 96-well, v-bottom microplate | 96-well racks with Matrix™ storage tubes | 96-well racks with Matrix™ storage tubes |
| Storage Temperature | -20°C | -20°C | -20°C |
| Stability (for at least) | 6 months, prior to opening | 6 months | 6 months |
Coronavirus strains and propagations hosts
To test antiviral compounds, researchers need access to virus isolates. To support this need, ATCC provides viral strains and propagation hosts. However, during the outbreak of a novel virus like SARS-CoV-2, it can be challenging to determine which propagation host is ideal for successful viral replication. In a recent study by Harcourt J, et al., it was discovered that SARS-CoV-2 can replicate to a high titer in Vero CCL-81 and Vero E6 cells in the absence of trypsin. These cell lines and the media needed to cultivate them are available at ATCC—explore our collection today.
Custom Services
We understand everyone’s research is unique.
If you cannot find the right tools for your drug repurposing needs, please contact our team at lifescience@invitro.com.au
Agilent Microplates and Seahorse Bioanalyser
To facilitate your liquid handling requirements in drug discovery workflow, Agilent offers a wide range of microplates including storage, assay, reservoir, and filter microplates.
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Storage & Assay Plates |
Reservoir
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Filter
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Accessories |
New Publication alert
This publication cites R&D Systems Ace2 polyclonal antibody as showing the capacity to block Novel Coronavirus virus entry.
> Read the publication now
> Find out more about the Ace2 polyclonal antibody
Coronavirus Research Resources
