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Apoptosis in Cancer

Cancer Apoptosis Panel 4Apoptosis IconInvestigating apoptosis is essential for understanding cancer biology and advancing cancer therapeutics. See the bigger picture in your cancer research by measuring apoptosis in real time using Promega’s range of simple sensitive fluorescent and luminescent assays. Sensitive and simple assays for publication-ready results.



RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay

PMJA1011 (100 assays), PMJA1012 (1000 assays)
ApoTox-Glo™ Triplex Assay PMG6320 (10mL), PMG6321 (5 x 10mL)

Caspase-Glo® 3/7 Assay System

PMG8090 (2.5mL), PMG8091 (10mL) , PMG8092 (100mL), PMG8093 (10 x 10mL)


Want to incorporate real-time assays into your research to get the full picture?

> Watch the webinar


Introduction to Apoptosis

Promega RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay

ja1011 realtime glo annexin v apo and nec asay 3The RealTime-Glo™ Annexin V Apoptosis and Necrosis Assay measures the real-time exposure of phosphatidylserine (PS) on the outer leaflet of cell membranes during the apoptotic process.

The reagent contains Annexin V luciferase fusion proteins that bind to PS during early apoptosis and are detected with a simple luminescence signal. A DNA-binding dye, enters the cell and generates a fluorescent signal upon loss of membrane integrity.

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How the assay works

Assay how it works

See how the Realtime Glo Annexin V and Apoptosis assay was used in the development of liposome -based treatments towards lung cancer

> Read the Article


Promega ApoTox-Glo™ Triplex Assay

g6320Measure Viability, Cytotoxicity, and Apoptosis in the same sample well using one assay containing:

  1. A fluorescent marker to measure cell viability
  2. A second fluorescent marker to measure loss of membrane integrity simultaneously
  3. A luminescent marker to monitor apoptosis

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Apo Tox Glo Results



See how ApoTox-Glo was used to assess nanoparticle therapeutics against ovarian cancer

> Read the Article


Promega Caspase-Glo® 3/7 Assay System

g8210 caspase glo 9 assay 2 5ml 3Caspase Glo Detection of Caspase ActivityThe Caspase-Glo® 3/7 assay provides a proluminescent caspase-3/7 DEVD-aminoluciferin substrate and a proprietary thermostable luciferase in a reagent optimized for caspase-3/7 activity, luciferase activity and cell analysis.

The stabilized luciferase and proprietary buffer system improve assay performance across a wide range of assay conditions, and the assay is less likely to be affected by compound interference than fluorescent- or colorimetric-based assays. The caspase activity assay is designed for use with multiwell plate formats using either purified enzyme or cells in culture and can be multiplexed with other cell-based assays. High sensitivity allows use of the Caspase-Glo® 3/7 assay in 3D cell culture systems.



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Learn more about apoptosis assays here

> Read the Article


Explore Promega’s Other Cancer Resources

Cancer Cell Health Panel

Tumor Analysis 4