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At In Vitro Technologies, we are always striving to provide a solution to your research needs. Through brands like ATCC, R&D Systems, Tocris and CelVivo, we bring you various cell-based model systems for drug screening and toxicology. Learn more about the primary cells, cell lines, stem cells, 3-D cell culture models, and more complex tissue and organ modeling systems here.

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A collection of assays is commonly used to examine the Absorption, Distribution, Metabolism, and Excretion of a drug or compound by cells in the body. This battery of testing is collectively referred to as ADME/Tox. The use of primary hepatocytes for ADME/Tox studies is an important step in evaluating drug safety and developing its pharmacokinetic profile.

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toxicology Webinar Video ATCCCredible models for every stage of your toxicological studies

Harmful substances can be present in pharmaceutical drugs, and the testing of these substances determines the degree of toxicity. This will often determine the fate of whether a new drug progresses through the development pipeline. It is critical that the standards and model organisms used in toxicological testing are reliable and authenticated. We can help streamline your research by providing the most authenticated, advanced, and functional models available. Let ATCC revolutionize and accelerate your toxicology studies in every phase of the research and testing process.

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Credible models yield incredible results

ATCC provides the cells, media, and reagents needed to explore each step of the in vitro preclinical testing process—from modeling, screening, and characterization to exploratory toxicology, pharmacokinetics, and metabolism. We provide renal, neural, airway, and skin cells for such applications as high-content screening, 3-D culture, spheroid culture, permeability assays, metabolic stability and survival studies, transport activity measurement, and more.

Download our toxicology portfolio brochure to explore solutions for your screening studies

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Tocriscreen DiagramTocriscreen™ Compound Libraries for 3D models and stem cells

High purity bioactive compound libraries for:

- Receptor de-orphaning
- Target validation
- Drug re-profiling
- Tool compound identification
- Assay development
- Custom compound library service

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Determining toxicity is a major need and it is challenging

The ClinoStar in vitro 3D spheroid system that can be used for determining toxicity. As described by Fey et al 2020.

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Toxicol Res, Volume 9, Issue 4, July 2020, Pages 379–389,

Toxicity must be assessed using both short-term (single dose, 24–48h; acute) and long-term (multiple doses, weeks to months; chronic) culture conditions. This is because drug induced liver injury (DILI) can develop following a single acute exposure as well as from repeated chronic treatment (e.g. by development of drug tolerance or deposition of metabolites)​. Long term treatment is especially important because it corresponds to the usual treatment regimen for patients but is difficult to replicate in an in vitro system.

Animals have proven not to be an accurate model and 40–50% of the drug candidates associated with hepatotoxicity in humans did not present the same toxicological concerns in animal models.​

One of the reasons for this discrepancy is the differential expression and activity of drug metabolising enzymes between animals and humans that might confound the extrapolation of data derived from model species.

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