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In Vitro Technologies announces a new partnership with ATCC®, the American Type Culture Collection.

ATCC’s collections include a wide range of biological materials for research, including cell lines, molecular genomics tools, microorganisms, and bioproducts. The organisation holds a collection of more than 3,400 human, animal, and plant cell lines. The molecular genomics collection at ATCC contains 8 million cloned genes from a host of species, including human, mouse, soybean, rat, monkey, zebrafish, and several disease vectors.

ATCC’s microorganism collection includes more than 18,000 strains of bacteria, 2,000 different types of animal viruses, and 1,000 plant viruses. In addition, ATCC maintains collections of protozoans, yeasts, and fungi, with over 49,000 yeast and fungi strains, and 2,000 strains of protists.

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Accelerate your vaccine and gene therapeutic development projects

The continual spread of deadly viruses necessitates the development of novel prevention and treatment options; however, the development of a new antiviral vaccine can be challenged by low-yielding manufacturing processes. Similarly, the development of gene therapies is constrained during the large-scale production of adeno-associated virus (AAV) delivery platforms for gene transfer.

To speed the pace of these various areas of bioproduction, ATCC addressed the need for efficient viral replication by optimizing three cell lines commonly used in virus manufacturing. Here, we used CRISPR/Cas9 gene-editing technology to develop STAT1 and BAX knockout cell lines capable of producing high-titer viral stocks. These newly created cell lines can produce model clinical viruses and adeno-associated viruses at titers much higher than the parental cell lines, providing an efficient method for biopharmaceutical companies to increase production while reducing associated costs.  Discover how these advanced biological models can be used in your vaccine and gene therapeutic development projects.

ATCC
293.STAT1 BAX KO

This STAT1 BAX double knockout HEK-293 cell line exhibits significant increased viral titer and enhanced virus production capability.

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MDCK.STAT1 KO

For influenza vaccine production, influenza propagation, and production of high-titer influenza stocks.

ATCC
Vero.STAT1 KO

For viral vaccine production including virus propagation, production of high-titer viral stocks, and rescue of clinical viral isolates.

 

Browse by Product Area

Please find your products on the ATCC website below and then contact us on lifescience@invitro.com.au for local pricing and availability.

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