PTEN Genetic Alteration Cell Line Panel Item ID: ATCTCP1030
| Permits and Restrictions |
View Permits |
|---|---|
| Organism | Homo sapiens, human |
| Components | ATCC CRL-1718 CCF-STTG1 ATCC HTB-111 AN3 CAATCC HTB-31 C-33-AATCC HTB-66 RPMI-7951ATCC HTB-148 H4ATCC HTB-12 SW 1088ATCC CRL-1585 C32ATCC CRL-1620 A172ATCC HTB-1 J82ATCC CRL-11730 TOV-21G |
| Applications | This panel is useful for PTEN pathway and PI3K pathway research and for anti-cancer drug discovery. |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments |
PTEN is a tumor suppressor gene that encodes for a lipid phosphatase protein that down-regulates PI3K activity, which in turn affects the AKT signaling pathway and regulation of the cell cycle. Mutations in this gene are associated with a variety of cancers, including brain, skin and ovarian. The PTEN genetic alteration cell panel (ATCC TCP-1030) is composed of ten human tumor cell lines from common cancer types that carry PTEN mutations or PTEN deletions. The PTEN status of each cell line has been sequenced and validated by ATCC. This panel is useful for PTEN and PI3K pathway research and for anti-cancer drug discovery. |
| Product Format | frozen |
| Storage Conditions | LN vapor (less than -130°C) only |
| Permits |
These permits may be required for shipping this product to Australia:
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|---|---|
| Basic Documentation | Product Sheet Certificate of Analysis SDS |
| Other Documentation | Recommended Culture Conditions Genetic Alteration Panels - Brochure |