The Tantti® Monolith hyperporous polymer is specifically designed for downstream separation and purification of large biomolecules – particularly in the production of biologics (e.g. protein drugs, vaccines, antibodies etc.).
Tantti® Monoliths are now available as DuloCore™ pre-packed columns. The key differentiating characteristic, in comparison to traditional purification columns, is its highly connected macropore structure that confers superior porosity, which is ideal for purifying large biomolecules at high loads:
The figure below depicts purification of virus particles using a Tantti® column. The interconnected macropores allow samples to pass through the column easily, while capturing impurities.
Tantti® BioScaffolds platform technology creates highly ordered micro-porous 3D BioScaffold and UniTantrix™ Microcarrier, which can be prepared with a variety of biological materials (such as collagen or animal-free materials).
Tantti® SpherTantrix is a Degradable 3D Cell Culture Scaffold
Tantti® 3D Cell Culture scaffold has the following features:
The 3D bio-scaffold plays an important role in tissue engineering, oncology, regenerative medicine, drug screening and stem cell biology study.
What is UniTantrix™ Microcarrier?
In addition, the microcarrier is dissolved easily by specific enzymes and the cell recovery rate is almost 100%.
Tantti® Monolith has a unique global patent, we call it IMP method (In-Mold Polymerization) and we use In-Mold Polymerization to produce a highly connected honeycomb structure for the production of biological products and other related products. The process is expected to greatly break through the bottleneck of purification for macro molecules, especially accelerate the production of various biologic products such as protein, antibody analysis, exosome and viral particle purification, thereby effectively reducing the cost of protein drugs and vaccine production. In addition, this IMP technology can be used to adsorb and remove various trace substances, such as endotoxin, circulating tumor DNA, DNA impurities in the vaccine production process, host cell protein HCP, etc., for industrial application. From the laboratory research to the application of downstream purification and mass production process, Tantti’s IMP technology is a very pioneering idea and create excellent product value for downstream purification materials. We believe the monolith of Tantti can provide new solution for unmet need in the analysis and purification market.
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