Import Permit Requirements

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions. 

Additional post entry conditions 

Department of Health, Disability and Ageing import conditions for Francisella tularensis subsp. novicida:

1. The in vitro or in vivo work in laboratory animals with F. tularensis subsp. novicida must be conducted in a Physical containment level 3 facility (PC3) facility using PC3 practices as per Australian/New Zealand Standard Safety in Laboratories Part 3: Microbiological safety and containment (AS/NZS 2243.3:2022). Department of Health, Disability and Aged Care - Advice to Importers and End-users
2. The cultures of F. tularensis subsp. novicida that have been validated to be completely inactivated can be removed to a PC2 facility. A quality assurance process be put in place to ensure that inactivation steps are performed using a validated method, checked, recorded and retained for an audit process if required.       
3. Francisella tularensis is classified as a Security Sensitive Biological Agent (SSBA) under the National Health Security Act 2007 and the National Health Security Regulations 2018. Permit holders must comply with the SSBA Regulatory Scheme requirements for handling these agents* and are advised to contact the Department of Health and Aged Care for further information regarding their statutory obligations prior to importing the SSBAs:
   Laboratories and Pathogen Security Section
   Interim Australian Centre for Disease Control
   Department of Health, Disability and Ageing
   GPO Box 9848 MDP 14
   Canberra ACT 2601, Australia
   SSBA Hotline: +61 2 6289 7477
   Email: ssba@health.gov.au
   *The agent being handled is considered to be an SSBA if it is infectious, viable and pathogenic or an active toxin.

Department of Health, Disability and Aging advice to importers and end users for Francisella tularensis subsp. novicida:

1. A risk assessment must be conducted to ensure that all specific human health risks associated with in vitro use or in vivo use with imported pathogens are identified and managed.
2. A risk assessment must be conducted to ensure that all specific human health risks associated with in vitro use or in vivo use with imported pathogens are identified and managed.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. The goods must not deliberately be used in circumstances where recombination and reassortment events with any other virus could reasonably be expected to occur, including coinfection of animals or cell lines with related or homologous infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit, with the exception of:
   - Standard laboratory microorganisms and infectious agents as listed on the Department’s website
   - Approved starter cultures as listed on the Department’s website
   - Primate T-lymphotropic viruses 1, 2, and 3 (formerly Human T-cell Leukemia viruses)
   - Parainfluenza virus 5 (formerly Simian parainfluenza virus 5 (formerly Simian virus 5)(SV5))
   - Xenotropic murine Leukemia virus-related virus (XRMV)
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents, with the exception of:
   - Standard laboratory microorganisms and infectious agents as listed on the Department’s website
   - Approved starter cultures as listed on the Department’s website
   - Primate T-lymphotropic viruses 1, 2, and 3 (formerly Human T-cell Leukemia viruses)
   - Parainfluenza virus 5 (formerly Simian parainfluenza virus 5 (formerly Simian virus 5)(SV5))
   - Xenotropic murine Leukemia virus-related virus (XRMV)

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.                                                    
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.                  

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.      

END USE CONDITIONS            

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.      

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit, other than porcine papovavirus and C-type retrovirus.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents, other than porcine papovavirus and C-type retrovirus.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.                                                                                                                                                                                          

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, microorganisms, cell cultures or the environment, and must not be used in or on humans.

Additional End Use Conditions

Department of Health and Aged Care - Import Conditions

1. All work with the goods must be conducted in Physical containment level 2 (PC2) or higher facility using PC2 work practices and containment equipment as per the Australian/New Zealand Standard Safety in Laboratories Part 3: Microbiological safety and containment (AS/NZS 2243:3:2022). All procedures that may produce aerosols should be conducted in a class II biological safety cabinet (BSC).

Department of Health and Aged Care - Advice to Importers and End-users

1. A risk assessment must be conducted and documented to ensure that any specific hazards relevant to the pathogen and the activity being conducted are identified and managed.
2. Personnel should be monitored for any symptoms of infection and provided with prompt first aid following any potential exposure incident."

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

Additional End Use Conditions

1. All work with the goods must be conducted in Physical containment level 2 (PC2) or higher facility using PC2 work practices and containment equipment as per the Australian/New Zealand Standard Safety in Laboratories Part 3: Microbiological safety and containment (AS/NZS 2243:3:2022). All procedures that may produce aerosols should be conducted in a class II biological safety cabinet (BSC).
2. Lomentospora spp. must be handled using appropriate precautions including use of Class II biological safety cabinet where there is risk of aerosol production.

Department of Health and Aged Care - Advice to Importers and End-users

1. A risk assessment must be conducted and documented to ensure that any specific hazards relevant to the pathogen and the activity being conducted are identified and managed.
2. Personnel should be monitored for any symptoms of infection and provided with prompt first aid following any potential exposure incident."

Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

Department of Health and Aged Care advice to End Users - Advice to End-users of Plasmodium falciparum

1. Laboratories and animal houses must be screened from mosquitoes to prevent exposure to potential vectors of Plasmodium.
2. Personnel should be monitored for any symptoms of infection and provided with prompt first aid following any potential exposure incident. If personnel do become infected it is recommended that they do not travel to North Queensland, Northern Territory or other areas where permissive vectors are present.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, or the environment, and must not be used in or on humans.
2. Microorganisms and derivatives thereof requiring an AA site as a class 5 approved arrangement site. 
3. The goods and their derivatives must not be removed from these sites, except for disposal or export, without the prior approval of the Director of Biosecurity.
4. The level of containment must be BC 2 or higher.
5. Where more than one approved arrangement site is listed, the samples must only be transferred between the listed sites. All records of transfer must be maintained for audit purposes.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, or the environment, and must not be used in or on humans.
2. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit, with the exception of Epstein-Barr Virus, Human hepatitis virus (A, B, C, D, G and TTV), Human herpes virus 1-8 and/or Parainfluenza virus 5.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents, with the exception of Epstein-Barr Virus, Human hepatitis virus (A, B, C, D, G and TTV), Human herpes virus 1-8 and/or Parainfluenza virus 5.
   
4. It is the end users responsibility to notify the Department of Agriculture, Fisheries and Forestry if an infectious agent is cultured or isolated, other than those listed above.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit, with the exception of Epstein-Barr Virus, Human hepatitis virus (A, B, C, D, G and TTV), Human herpes virus 1-8 and/or Parainfluenza virus 5. 
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents, with the exception of Epstein-Barr Virus, Human hepatitis virus (A, B, C, D, G and TTV), Human herpes virus 1-8 and/or Parainfluenza virus 5.
4. It is the end users responsibility to notify the Department of Agriculture, Fisheries and Forestry if an infectious agent is cultured or isolated, other than those listed above.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must be used for nucleic acid sequencing only.
2. The goods must not be exposed to or used in animals, plants, microorganisms, cell cultures or the environment, and must not be used in or on humans.
3. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. The goods may be used for the culturing and isolation of microorganisms and infectious agents, including the following:
   2.1. Propagating microorganisms and infectious agents from the goods, and/or
   2.2. inserting or inoculating microorganisms or infectious agents into eukaryotic or prokaryotic cell cultures.
3. Synthesis of replication-competent microorganisms, infectious agents, or homologues from the goods is restricted to plasmids that are non-conjugative and non-integrative, and not made for the purpose of creating/transcribing or expressing a separate replication competent infectious agent.
4. The goods must not deliberately be used in circumstances where recombination and reassortment events with any other virus could reasonably be expected to occur, including coinfection of animals or cell lines with related or homologous infectious agents.
5. Imported material and derivatives are not to be used with genes derived from and/or associated with, or homologous to the following without further assessment by the Department of Agriculture, Fisheries and Forestry:
   5.1. Pathogens of animal biosecurity concern for biological products, as published on the Department of Agriculture, Fisheries and Forestry's website.
   5.2. Disease agents causing Listed Human Diseases, as legislated under the Biosecurity (Listed Human Disease) Determination 2016 and published on the Federal Register of Legislation.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, or the environment, and must not be used in or on humans.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, cell cultures or the environment, and must not be used in or on humans (except for allergy tests to be applied to the skin).
2. The goods must not be used for culture or isolation of microorganisms and infectious agents.
3. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.
4. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, or the environment, and must not be used in or on humans.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, cell cultures or the environment, and must not be used in or on humans (except for allergy tests to be applied to the skin).
2. The goods must not be used for culture or isolation of microorganisms and infectious agents.
3. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.
4. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must only be used for human therapeutic or research purposes.
2. The goods must not be exposed to or used in animals, plants, cell cultures or the environment.
3. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.
4. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

Additional End Use Conditions

Department of Health and Aged Care end use conditions

All diagnostic samples and human derived materials contained within the goods must be handled using standard precautions as outlined in the Australian Guidelines for the Prevention and Control of Infection in Healthcare, as published on the National Health and Medical Research Council website.

Department of Health and Aged Care – Advice to importers and end users

A risk assessment must be undertaken to ensure that any specific hazards depending on the particular end use are identified and managed.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

Additional End Use Conditions

Dengue virus

1. Work must be conducted in Physical Containment (PC2) facility, or higher. The facility must use PC2 work practices as recommended under the Australian/New Zealand Standard Safety in laboratories Part 3: Microbiological safety and containment (AS/NZS2243.3:2022).
2. Class 2 biological safety cabinets are to be used for all manipulations that may cause splashes, droplets or aerosols.
3. No work with Dengue virus is to be conducted in close proximity to an insectary housing permissive vectors.

Leishmania spp, Influenza B and Mycoplasma genitalium

1. Work must be conducted in Physical Containment (PC2) facility, or higher. The facility must use PC2 work practices as recommended under the Australian/New Zealand Standard Safety in laboratories Part 3: Microbiological safety and containment (AS/NZS2243.3:2022).
2. Class 2 biological safety cabinets are to be used for all manipulations that may cause splashes, droplets or aerosols.

Department of Health and Aged Care advice to End Users

Dengue virus

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Following any potential exposure incident, personnel must be provided with prompt first aid, be evaluated by a medical professional and monitored for any symptoms of infection.
3. If personnel do become infected with Dengue virus, it is recommended that they do not travel to North Queensland or other areas where permissive vectors are present.

Influenza B virus

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Following any potential exposure incident, personnel must be provided with prompt first aid, be evaluated by a medical professional and monitored for any symptoms of infection.
3. It is recommended that personnel working with the virus be immunised with a seasonal influenza vaccine and be monitored for any influenza-like symptoms.

Leishmania spp and Mycoplasma genitalium

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Following any potential exposure incident, personnel must be provided with prompt first aid, be evaluated by a medical professional and monitored for any symptoms of infection.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, microorganisms, cell cultures or the environment, and must not be used in or on humans.

Additional End Use Conditions

Zika virus

1. Work must be conducted in Physical Containment (PC2) facility, or higher. The facility must use PC2 work practices as recommended under the Australian/New Zealand Standard Safety in laboratories Part 3: Microbiological safety and containment (AS/NZS2243.3:2022).
2. Class 2 biological safety cabinets are to be used for all manipulations that may cause splashes, droplets or aerosols.It is recommended that large-scale culturing of Zika virus (in volumes over 1 litre) is conducted in a PC3 facility using PC3 work practices.
3. No work with Zika virus is to be conducted in close proximity to an insectary housing permissive vectors. The definition of ‘close proximity' should be risk-based. It should be considered in terms of the ‘likelihood’ of any permissive vectors being present in nearby insectaries and more broadly in the local vicinity, as part of an ongoing assessment of this risk, where the likelihood may increase from time-to-time. The ongoing risk assessment must also take into consideration where the laboratory animals are housed, for example, under laboratory or animal house conditions.
4. The involvement of pregnant workers in studies with Zika virus must be avoided. All women of child bearing age should be made aware of the risks posed and understand the need to be mindful of potential exposure in case they become pregnant.
5. Zika virus can be transmitted sexually, therefore personnel with partners who are pregnant or are considering pregnancy should be aware of the risk associated with sexual transmission of Zika virus.

Department of Health and Aged Care advice to End Users

Zika Virus

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Following any potential exposure incident, personnel must be provided with prompt first aid, be evaluated by a medical professional and monitored for any symptoms of infection.
3. If personnel do become infected with Zika virus, it is recommended that they do not travel to North Queensland or other areas where permissive vectors are present.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.

Additional End Use Conditions

1. Work must be conducted in Physical Containment (PC2) facility, or higher. The facility must use PC2 work practices as recommended under the Australian/New Zealand Standard Safety in laboratories Part 3: Microbiological safety and containment (AS/NZS2243.3:2022).
2. Class 2 biological safety cabinets are to be used for all manipulations that may cause splashes, droplets or aerosols. No work with Dengue virus is to be conducted in close proximity to an insectary housing permissive vectors.

Department of Health and Aged Care advice to End Users

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Following any potential exposure incident, personnel must be provided with prompt first aid, be evaluated by a medical professional and monitored for any symptoms of infection.
3. It is recommended that personnel working with the virus be immunised with a seasonal influenza vaccine and be monitored for any influenza-like symptoms.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, microorganisms, cell cultures or the environment, and must not be used in or on humans.
2. The goods must not be used for culture or isolation of microorganisms and infectious agents.
3. Microorganisms or infectious agents must not be cultured or isolated from the materials imported under this permit.
4. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

Additional End Use Conditions

1. Work must be conducted in Physical Containment Level 2 (PC2) facility, or higher. The facility must use PC2 work practices as recommended under the Australian/New Zealand Standard Safety in laboratories Part 3: Microbiological safety and containment (AS/NZS2243.3:2022).

Department of Health and Aged Care advice to End Users

1. A risk assessment must be conducted and documented to ensure that any specific hazards, relevant to the pathogen and the activity being conducted, are identified and managed.
2. Personnel must be monitored for any symptoms of infection and provided with prompt first aid and evaluation by a medical professional following any potential exposure incident. 

END USE CONDITIONS

1. The goods must not be exposed to or used in animals, plants, or the environment, and must not be used in or on humans.
2. Microorganisms and derivatives thereof requiring an AA site as a class 5 approved arrangement site.
3. The goods and their derivatives must not be removed from these sites, except for disposal or export, without the prior approval of the Director of Biosecurity.
4. The level of containment must be BC 2 or higher.
5. Where more than one approved arrangement site is listed, the samples must only be transferred between the listed sites. All records of transfer must be maintained for audit purposes.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
3. Any microorganisms or infectious agents (including derivatives) within the goods must not be used for the synthesis of replication-competent microorganisms or infectious agents.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. The goods must not deliberately be used in circumstances where recombination and re-assortment events with any other virus could reasonably be expected to occur, including coinfection of animals or cell lines with related or homologous infectious agents. 
3. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.
4. Synthesis* of replication competent microorganisms, infectious agents or homologues from the goods is restricted to plasmids that are non-conjugative and non-integrative, and not made for the purpose of creating/transcribing or expressing a separate replication competent infectious agent.

* Synthesis of replication-competent microorganisms, infectious agents or homologues refers to the process of modifying or constructing microorganisms and infectious agents which can replicate within eukaryotic or prokaryotic cells.

END USE CONDITIONS

1. The goods must not be exposed to or used in animals other than laboratory animals and must not be used in any plants, humans or the environment. Laboratory organisms are guinea pigs, hamsters, mice, rats, rabbits or microorganisms contained under laboratory or animal house conditions.
2. The goods must not deliberately be used in circumstances where recombination and reassortment events with any other virus could reasonably be expected to occur, including coinfection of animals or cell lines with related or homologous infectious agents.
3. Microorganisms or infectious agents must not be intentionally cultured or isolated from the materials imported under this permit.

Synthesis* of replication competent microorganisms, infectious agents or homologues from the goods is restricted to plasmids that are non-conjugative and non-integrative, and not made for the purpose of creating/transcribing or expressing a separate replication competent infectious agent.

* Synthesis of replication-competent microorganisms, infectious agents or homologues refers to the process of modifying or constructing microorganisms and infectious agents which can replicate within eukaryotic or prokaryotic cells.