Spatial Biology
Uncover the spatial biology dimension with confidence.
At In Vitro Technologies, we understand the importance of unravelling the mysteries hidden within the spatial organization of biological systems. Together with Bio-techne, we offer cutting-edge spatial biology solutions that empower researchers, clinicians, and innovators to gain unprecedented insights into the complex architecture of tissues, paving the way for ground-breaking discoveries and applications.
Why use RNAscope ISH?
Standard molecular methods for disease profiling rely on dissociated cells that results in a loss of spatial information. However, a more complete and contextual understanding of the molecular mechanisms underlying cellular behavior requires complementary information on the subcellular localization of events, something that is only possible by use of in situ hybridization. Inspired to solve these challenges, Scientists at Advanced Cell Diagnostics, a Bio-Techne brand, revolutionized the RNA in situ hybridization method and in 2011 introduced RNAscope ISH for detection of target RNA within intact cells. The assay represents a major advance in RNA ISH approaches, with its proprietary probe design that simultaneously amplify target-specific signals and suppress background noise from non-specific hybridization. Known for its sensitivity and specificity, RNAscope ISH is now a proven pioneering technology in the advancing field of spatial genomics, featured in over 10,000 publications across a multitude of research areas.
Which RNAscope is right for me?
White Paper: A guide to RNA as a
biomarker and its detection
RNAscope™ Assay
RNA expression like you’ve never seen before. Detect mRNA and ncRNA targets of >300bp
BaseScope™ Assay
Enables the specific detection of exon junctions, short target/splice variants highly homologous sequences and point mutations
Automated Assays
For labs that require high throughput and automated RNA in situ hybridization (ISH) analysis
CiteAb Awards
CiteAb 2024 Award Winner
This kit enables high-plex spatial co-detection of RNA and protein markers for the Standard BioTools Hyperion™ Imaging Mass Cytometry (IMC) System. This technology caught our judges' eye as a really powerful research tool to help advance discovery.
CiteAb 2024 Highly Commended
"The Highly Commended Honor given to our ACD brand underscores our Spatial Biology team's dedication to enriching our customers' experiences and prioritizing researchers' needs."
- Kim Kelderman President & CEO of Bio-Techne