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In Vitro Technologies enables researchers to accelerate discovery when investigating both the impacts of neurotransmitters and to analyse neurotransmitter and neuroreceptor expression with a unique portfolio of reagents and equipment specialised for neurotransmission research.

Neurotransmission, or synaptic transmission, involves the passage of signals by electrical or chemical means from one neuron to another. It allows communication between nerve cells for the propagation of electrical impulses to and from the central nervous system leading to the co-ordination of secretion, muscle contraction and organ function.


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A fine synchronization between neurotransmitters and neuroreceptors is required for optimal functioning of the nervous system, and analysis of neurotransmitters as well as neuroreceptors expression is very critical for physiological and pathological neuroscience experiments.

> Spark your research potential with In Vitro Technologies


Investigating neurotransmission pathways in Neurodegenerative diseases

Tocris Biosciences enables researchers to study the impacts of neurotransmitters with a wide range of chemical inhibitors and antagonists. The use of small molecule inhibitors and antagonists to facilitate neurotransmission research has helped delineate the pathways involved in many neurodegenerative diseases, as well as providing a solid foundation for the development of future targeted therapeutics. Tocris provides an innovative range of high performance life science reagents for use in neurodegeneration research, equipping researchers with selective pharmacological tools for studying these disease pathways.


Tocris Product Name



Key Research Area

SR 144528 (#5039)

Potent and selective CB2 receptor inverse agonist

Orally bioavailable

Alzheimer’s disease

JNJ 63533054 (#5666)

Potent and selective GPR139 agonist

Orally bioavailable and brain penetrant


AZD 3147 (#5615)

Potent and selective MTORC1/2 inhibitor (IC50 = 1.5 nM)

Orally available

Alzheimer’s disease

PF 3084014 (#5751)

Potent γ-secretase inhibitor (IC50 = 1.2 nM)

Reduces Amyloid β levels in the brains of mice

Alzheimer’s disease

ML 352 (#5725)

Selective inhibitor of presynaptic choline transporters (CHTs)

CHTs transport choline into presynaptic neurons for the synthesis of acetylcholine (a neurotransmitter)


BI 9564 (#5590)

Potent and selective bromodomain (BRD) 7/9 inhibitor

BRDs are regions of certain proteins that bind to histones adjacent to DNA, enabling the protein to influence gene expression. Cell permeable and orally active.

Multiple sclerosis

A 971432 (#5766)

Potent and selective sphingosine phosphate receptor S1P5 agonist

Reverses age-related cognitive decline in mice




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