Novus TACI/TNFRSF13B/CVID Antibody (1A1) [Biotin], 0.1 mg Item ID: NOVNB10077912

TACI/TNFRSF13B/CVID Antibody (1A1) [Biotin] Summary

Immunogen	Tissue / cell preparation (Human) - human TACI transfected into rat RBL cells.
Localization	Type III membrane protein
Specificity	TACI (1A1)
Isotype	IgG2a
Clonality	Monoclonal
Host	Rat
Gene	TNFRSF13B
Purity	Protein G purified
Innovator's Reward	Test in a species/application not listed above to receive a full credit towards a future purchase.Learn about the Innovator's Reward

Applications/Dilutions

Dilutions	Flow Cytometry 1:10-1:1000
Application Notes	Flow Cytometry Use at an assay dependent dilution. Used with transfected cells and blood B cells. Not tested in other applications.Optimal dilutions/concentrations should be determined by the end user. Detects endogenous protein.
Readout System	Streptavidin Native Protein Streptavidin Native Protein Streptavidin Native Protein
Positive Control	TACI/TNFRSF13B/CVID Lysate (NBL1-17148)

Packaging, Storage & Formulations

Storage	Store at 4C. Do not freeze.
Buffer	PBS (pH 7.2)
Preservative	0.09% Sodium Azide
Concentration	0.5 mg/ml
Purity	Protein G purified

Alternate Names for TACI/TNFRSF13B/CVID Antibody (1A1) [Biotin]

• CD267 antigen
• CD267
• CVID
• CVID2
• FLJ39942
• MGC133214
• TACI
• TACIMGC39952
• TNFRSF13B
• TNFRSF14B
• Transmembrane activator and CAML interactor
• tumor necrosis factor receptor 13B
• tumor necrosis factor receptor superfamily member 13B
• tumor necrosis factor receptor superfamily, member 13B

Background

TACI, Transmembrane Activator CAML (calcium modulator and cyclophilin ligand) Interactor, is a 32 kD type III transmembrane protein. It belongs to TNF receptor superfamily, known as TNFRSF member 13B (TNFRSF13B) or CD267. TACI is expressed on B cells, and myeloma cells. TACI contains 2 cysteine-rich domains (CRDs). Recent studies, however, have shown that another shorter form (TACI_d2) of TACI exists wherein the N-terminal CRD is removed by alternative splicing. TACI_d2 contains full affinity for its ligands. Several proteins (BAFF/BLys, APRIL, Syndecan-2) have been identified as TACI ligands. The interaction of TACI with its ligands induces activation of the transcription factors NFAT, AP1, and NF- kappa B and plays a crucial role in humoral immunity by negative regulation of B cell proliferation and survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.