R&D Systems AI Modified Proteins
Overcome Cell Culture Challenges with R&D Systems AI Modified Proteins
Discover the future of protein design with R&D Systems designer proteins, an advanced solution to overcoming cell culture challenges. Engineered using cutting-edge technologies such as generative AI (artificial intelligence), protein library evolution, and rational design, these innovative proteins deliver critical benefits resulting in enhanced cell culture performance, including:
- Optimized cell expansion
- Longer stability in media
- Superior biological activity
- Streamlined workflows and a path to clinical applications
Our state-of-the-art designer proteins mirror the biological functionality of their wild-type counterparts while introducing optimized features to meet the evolving demands of cell therapy workflows and research applications.
With tailored functionalities such as hyperactivity, improved receptor affinities, enhanced workflow efficiency, and heat stability, our new designer cytokines and growth factors represent a breakthrough in cell culture innovation.
Proteins Designed for Thermal Stability
Engineered for stability at high temperatures, our heat stable proteins maintain high bioactivity in cell culture for longer periods than the corresponding wild-type protein.
Heat Stable Proteins
Ideal for cell therapy applications, heat stable proteins ensure:
- Improved Stability: Higher activity retention than wild-type counterparts, able to withstand high temperatures and extended culture durations
- Consistent Cultures: Increased stability in media over extended durations allows for greater consistency throughout cell culture workflows
- Reliable Performance: Heat Stable IL-2 promotes CD8+/CD4+ T cell outgrowth similar to the standard IL-2 protein, with comparable T cell phenotypes
- Seamless Path to Clinic: Our research-grade, Animal-free Preclinical, and GMP-grade FGF basic Heat Stable Proteins show equivalent bioactivity, ensuring performance continuity from research to clinical applications
IL-2 Heat Stable Agonist Protein
Explore the benefits of IL-2 Heat Stable Agonist Protein, which can withstand high temperatures and extended culture durations
FGF basic Heat Stable Protein
Optimize workflows with FGF basic Heat Stable Protein, designed to retain activity at high temperatures for extended cultures
Proteins Designed for Efficiency
Engineered to be water-soluble and easier to purify, our Wnt/R-Spondin Agonist Proteins effectively activate canonical Wnt signaling.
Wnt/R-Spondin Agonist Proteins
Key reagents for advancing stem cell research, organoid development, and regenerative medicine, these proteins offer:
- All-in-One Activation: Reduce experimental complexity with a single, cost-effective protein
- Streamline Workflows: Save time with a well-defined reagent to substitute for conditioned media or the addition of two individual proteins
- Reliable Performance: Effectively promotes Wnt receptor activation and canonical Wnt signaling
- Increased Solubility: More amenable to media formulations than traditional Wnt proteins
Wnt/R-Spondin Agonist Proteins
Learn about Wnt/R-Spondin Agonist Proteins,
offering an all-in-one approach to
Wnt signaling activation and increased solubility.
Proteins Designed for Affinity
Engineered to engage target receptors with higher affinity, these proteins show improved binding and cell expansion compared to their standard protein counterparts.
IL-2 (CD122-Directed) Protein
Ideal for large scale CAR T-cell or TIL expansion, this protein ensures:
- Enhanced CD122 Binding: Displays increased affinity to the IL-2 beta receptor (CD122) with decreased affinity to the IL-2 alpha receptor (CD25), resulting in more effective expansion of effector T cells
- Improved Output: Maintains growth of CD8+/CD4+ T cells for workflows requiring extended T cell proliferation
- Sustained Potential: Improved proliferation capacity and enhanced naive population without increased exhaustion of T cells
Proteins Designed for Hyperactivity
Engineered for enhanced bioactivity, hyperactive proteins demonstrate superior performance compared to the corresponding wild-type protein.
Activin A Hyperactive Protein
Optimized for superior performance in regenerative medicine cell differentiation applications, this protein gives:
- Enhanced Activity: Cost-effective protein provides 4-fold higher activity than the wild-type Activin A protein, allowing less protein to be used to achieve the same potency
- Confidence in Performance: Promotes efficient endoderm differentiation in human iPSC lines
- Reliable Results: Efficient derivation of PDX1+/NKX6.1+ pancreatic progenitors that is comparable to the wild-type protein
Read about our new Activin A Hyperactive Protein,
exhibiting 4-fold higher activity than the wild-type protein.
Additional resources
Animal Component-Free iPSC Expansion Media
ExCellerate iPSC Expansion Media are designed for feeder free expansion and maintenance of human iPSCs. Available in both research use only (RUO) and GMP versions, these all-in-one formulations simplify media preparation for robust stem cell cultures.
Best Practices for iPSC Culture and Differentiation Webinar
Hear from Dosh Whye, Assistant Director at Human Neuron Core, Boston Children’s Hospital, as he guides you through the key techniques for overcoming the challenges of maintaining pluripotency and achieving successful stem cell differentiation.
