Hi, my name is Maurice. I am the workhorse station for purity, identity and heterogeneity analysis.
Need cIEF and CE-SDS data for your mAbs, ADCs, vaccines or virus-like particles? Maurice does it all. Just pop in one of the preassembled cartridges, drop in your sample vials or a 96-well plate, and hit start. You will complete method development in a day; and get high-resolution, reproducible data in minutes.
cIEF and CE-SDS Analysis
• Automated, high-resolution protein profiling by charge (cIEF) or size (CE-SDS) – easily switch between c IEF and CE-SDS using pre-assembled cartridges
• Development of platform methods in a day
• Acquire pI and charge heterogeneity data in less than 10 minutes and CE-SDS data in 35 minutes
• Analyse mAbs, ADCs, vaccines, virus-like particles etc.
cIEF
CE-SDS
- - High-resolution characterisation of charge variants using proprietary whole-column detection capillary isoelectric focusing (icIEF) technology
- - Prequalified, ready-to-use cartridge design which fully automates column conditioning and clean up.
- - pI and charge heterogeneity data in less than 10 minutes. Size-based CE-SDS data in 35 minutes.
- - One-day method development, or analyse 48 to 100 samples in one batch.
- - Minimise cross-contamination. Completely separate fluid paths for cIEF/CE-SDS applications and waste is collected inside the cartridge
- - Native fluorescence detection for cIEF provides 3-5X higher sensitivity (up to 0.7 µg/ml) than UV absorption
- - Can reduce or even eliminate urea completely in some methods.
- - Compass for iCE, the software package Maurice uses to acquire, manage and analyse data, has all the tools required for 21 CFR compliance so you'll have no issue analysing biotherapeutics on Maurice in a regulated environment.
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