C-CIT Sensors aims to revolutionize the fields of upstream bioprocessing, cell therapy and regenerative medicine by enabling the continuous in-situ metabolic monitoring and automated process control.

C-CIT Sensors offer you the only, on-line, real-time glucose & lactate monitoring solution for bioprocess.

Enzyme based chemistry (high specificity for the substrate)
Gamma-irradiated Sensors available in several formats
Achieve higher product yields and reduce manual routine work with automated monitoring

Fill in the form to Access & Download the latest poster from University of Applied Sciences, Bielefeld, Germany, where this system was tested in multiple Fed-batch-cultivations with various CHO cell lines.

Key findings:

Ability of the CITSens APC-system to maintain a constant glucose concentration at various thresholds over the cultivation time of 14 days.
It could be shown that online glucose measurement generates comparable results to the established measurement via a Biochemistry Analyzer.
With this automated feeding system, it is possible to keep a constant low glucose concentration reliable over a long period.
Decrease the risk of contamination through human interaction

C-CIT Videos

Watch Video to learn about Process control based on glucose from smallest vessel to bioreactor scale

Watch Video to learn about C-CIT Sensors AG, in situ glucose and lactate sensors

Process Probe for SUB, one probe - two analytes

ProcessProbe e1558993183623 Probe for stirred single use bioreactors with PG 13.5 thread ports. One probe for in-situ monitoring of glucose and lactate for process development and process control. The probe is available in different length as well as packed in a clean connector for orbital shaked bags. The Sensor housing and coverage is made of USP VI certified material and the probe is gamma sterilized. Connected to our systems CITSens Bio or CITSens MeMo and a pump the probe can be used for media feed.

>Download the Technical Data Brochure

Systems to connect our process probe with glucose and lactate sensors

CITSens MeMo

CITSensMeMo e1558993297305

Continuous in-situ measurement of glucose and lactate
One sensor, one electronic, two analytes
Bluetooth communication

CITSens MeMo, monitoring and process control system with in-situ Glucose and Lactate sensors. It is made for in-situ monitoring of Glucose and Lactate with one sensor and can be used to control processes by metabolites. It makes Cell line selection easy and fast, allows optimized media & process development and improves science. The system increases yield of product and gives you remote control of your cell culture process. Data can be integrated in all kinds of process control systems. To the system CITSens MeMo a pump can be connected directly to do media feed. The glucose and lactate sensors are suitable for all kinds of reactors, shake flasks and other single-use vessels.

With CITSens MeMo Basic Version you get Tablet with monitoring Software and one transmitter (whether Bluetooth or wired). This version is limited to the use of one transmitter and has no automated process control (APC) Software.

You can decide to upgrade the Basic Version to a full version in a modular way depending on your needs. With CITSens MeMo Full Version you get Tablet with monitoring and automated process control (APC) softwares and 4 transmitters (whether Bluetooth or wired).
This version can be used up to 12x transmitters.

CITSens MeMo APC

CITSens APC 1 e1567514281565 1

Continuous in-situ measurement of glucose and/or lactate
Process control by direct connection of a pump to the system for media feed based on glucose
Full process control without sampling and manual feed
Connectivity to third party systems:
- EVE® Process Control Software of Infors HT
- Connectivity to ODBC for database exchange and OPC servers

CITSens MeMo APC are the first process control systems based on continuous in-situ Glucose and/or Lactate monitoring.
Our systems make cell line selection easy and fast, allow optimized media & process development and improve science. Thanks to our CITSens APC you will be able to control your cell culture process remotely and to reach higher product yields. The system measures glucose continuously and gives a feedback to a pump connected to the system for automated media feed. Data can be integrated in all kind of process control systems. The glucose and lactate sensors are suitable for all kind of reactors, shake flasks and other single-use vessels

Fill in the form to access our Introductory offer on the glucose and lactate sensors

CITSens MeMo allows you to measure glucose and lactate continuously and in-situ in cell cultures and to control processes by metabolites. The CITSens APC (Automated Process Control) with the integrated pump control even gives you the possibility to feed your cell culture according to glucose concentration fully automated. It allows total new process developments with continuous feed at every glucose level without manual sampling or feeding. All sensors and electronic components can also be customized.

Consumables for CITSens MeMo and CITSens APC
In-situ Glucose and Lactate sensors in different shapes for all types of bioreactors and vessels to measure glucose and lactate continuously and in real time.

C-CIT Sensors and Probes