siRNA Tools | Effective Gene Silencing Solution

Effective Gene Silencing Tools

siRNAs are effective gene-silencing tools delivered via lentivirus, AAV, plasmids, or dsRNA transfection. Our dual-promoter system eliminates the need for hairpin shRNA design, simplifying cloning and target gene knockdown.

abm’s lentiviral RNAi Expression System enables efficient siRNA delivery via transfection or infection. Its convergent promoter design improves gene knockdown without requiring hairpin structures. A broad library of human, mouse, and rat siRNAs is available in vector or pre-packaged lentivirus formats. 

Advantages

• Potent 27–29 bp siRNAs vs traditional 19–21 bp 
• Convergent promoters simplify cloning and sequencing
• Optional GFP reporter for real-time monitoring
• Available as 4-construct sets for stronger knockdown 

abm’s RNAi Expression System is available in AAV format, enabling efficient siRNA expression with non-integrating delivery for gene therapy.

Advantages of AAV siRNA

• 27–29 bp siRNAs for stronger knockdown
• Convergent promoters remove need for hairpin structures
• GFP reporter for real-time monitoring
• 3-construct pooled sets for improved silencing
• Low immunogenicity with no genomic integration

siRNAs enable rapid, transient gene knockdown via dsRNA delivery without altering the genome. Suitable for in vitro and in vivo use, ABM offers pre-designed 3-siRNA sets for any human, mouse, or rat gene, plus controls.

Key Features:

Lenti-siRNA Expression Systems Manual Click Here to Download

Publication 1

Hepatic TET3 contributes to type-2 diabetes by inducing the HNF4α fetal isoform, Da Li et al., Nature Communications (2020) Click Here