Immune Cell Therapy
Harness the power of the immune system for targeting cancer and autoimmune diseases. Our technologies will help you build a robust process to scale up your immune cell therapy and revolutionize the treatment of these life threatening diseases.
Cell Selection
Specific immune cell subsets (e.g. T cells, NK cells) are often separated from the apheresis material to obtain an enriched cell population for downstream genetic engineering and expansion. See below our extensive range of solutions.
Authenticated Primary Immune cells for designing and testing treatments as part of your research and development.
Luciferase Reporter Cancer Cell Lines to provide target cells for immuno-oncology researchers adopting BLI assays
Custom GMP antibodies for cell selection.
T cell marker antibodies and NK cell marker antibodies to confirm selection by flow cytometry.
Custom antibody conjugation with biotin or fluorochromes.
GMP ProDots Proteins formulated as dissolvable spheres enclosed inside sterile, weldable bags for closed processing cytokine addition.
Animal Free GMP Proteins produced in dedicated controlled access laboratories to prevent potential contamination by animal components or by products.
MagCellect™ cell Selection Kits for enriching cell populations by positive or negative selection without the need for specialized columns.
T cell enrichment columns that are designed to enrich for a specific T cell population from a mononuclear cell suspension.
GMP small molecules promote directed differentiation.
Cell Culture
Our extensive selection of media (including serum free media and serum replacement), reagents and equipment are designed specifically for cell therapy manufacturing. See below our extensive range of solutions.
ExCellerate™ human T cell or NK cell expansion media for serum free and xeno free expansion of cells from human PBMCs or purified CD3+ cells
Custom GMP media can be packaged in bags for direct welding into closed system processes.
Foetal Bovine Serum as an ideal growth supplement for cell culture media.
Stemulate® Xeno and heparin free pooled platelet lysate serving as a high performance FBS replacement.
T LIVEN PR™ GMP ready human platelet lysate for closed system bioprocessing.
nLiven PR™ GMP ready pathogen reduced human platelet lysate.
Insect Cell Culture Medium for a complete serum free, protein free medium developed to obtain robust cell growth.
Shakers and Bioreactors to culture your cells.
Cell Culture Supplements to optimize your culture media.
Fixed bed bioreactor for small to large scale production for early stage process development to clinical and commercial production.
Gene Editing
Gene editing techniques are increasingly being used to improve the targeting and efficacy of cell therapies. There are several methods of gene editing, including viral and non viral technologies. See below our extensive range of solutions.
TcBuster™ Gene Transfer System is non viral, transposon based system for improved integration rates compared to traditional methods
Maurice™ cIEF systems analyze the charge heterogeneity of your viral vector for stability and identity.
Simple Western™ systems monitor virus capsids during purification.
Simple Plex™ immunoassays for viral vector immunotitration.
STAT1 knockout cell lines capable of producing high titer viral stocks.
FectoVIR® AAV GMP for superior AAV titers with commercial scalability.
PEIPro offers optimized PEI based transfection for scalable virus production.
Expression Verification Target Validation
Before scaling up production of engineered immune cells, it is important to verify successful expression of the construct and function of the edited cells. A variety of methods are currently employed to verify expression and functionality. See below our extensive range of solutions.
GCLP compliant RNAscope™ ISH analysis offers single cell RNA expression analysis to localize your cell therapy in the target tissue.
Epitope Tag Antibodies for detection of tagged molecules in your genetic construct.
Monitor T Cell Exhaustion using reagents and assays to confirm that your cells don’t become over activated in vivo.
Cell Expansion
Cell culture expansion is a crucial step in immune cell therapy manufacturing. Specific combinations of reagents and equipment f rom our portfolio will promote robust cell expansion to meet therapeutic dosing requirements. See below our extensive range of solutions.
CellXVivo kits Immune Cell Differentiation or Expansion
Custom GMP media can be packaged in bags for direct welding into closed system processes.
Recombinant cytokines for Immune Cell Differentiation and expansion.
Cloudz™ Immune cell activation kit is based on dissolvable microspheres for >50 fold to >100 fold expansion of CD25+CD69+ T cells and NK cells from PBMCs
XF Hu T Cell Activation Assay for a quantitative and kinetic readout of T cell activation dynamics in real time.
Shaker and Bioreactors expanding your cells.
UniTantrix® Microcarriers for optimized cell yield suited for both scale up and large scale cell production.
Quantum Automated Cell Culture Platform that has been proven effective in the consistent expansion of adherent cells, suspension cells and viral vectors.
Fixed bed bioreactor for small to large scale production for early stage process development to clinical and commercial production.
Cell Phenotype & Characterization
Once cell cultures have been expanded, verification of cell phenotype and purity is required for product release. We offer expert analytic solutions and a full range of immunoassays, options for automated multianalyte analysis. See below our extensive range of solutions.
T cell marker antibodies and NK cell marker antibodies for cell characterisation.
Immune checkpoint blockade antibodies to confirm knockdowns of negative signalling molecules.
Fluorescent labelled proteins for direct ligand based cell analysis
Single Cell Westerns analyze heterogeneity of cell type, activation status, and gene transfer efficiency.
Luminex® assays enable multiplexing of key analytes to confirm phenotype. ELISA kits quantify production of single cytokines
Simple Plex™ automates multi analyte T cell or NK cell secretion profile analysis in 90 minutes.
Micro Flow Imaging characterizes and quantitates residual activation beads and protein aggregates.
Simple Western detects process related impurities.
Formulation of Final Product
Formulating the QC-released final cell product for delivery to the patient is important to maintain product viability during storage and transport. See below our extensive range of solutions.
FINIA® Fill and Finish System is a functionally closed benchtop system that automates all fill and finish steps involved.
CellSeal® AF 500™ Automated Fill and Seal System provides the path to scale up and standardize through increased accuracy, speed, and productivity
CellSeal® Cryogenic Vials that are ideal for both autologous and allogeneic products.
Signata CT 5™ Semi automated Fluid handling platform for closed system bioprocessing.
Tubing Welders and Sealers to reduce failure rates and maintain a closed system.
