T Helper Cells

CD4+ T cells play an integral role in adaptive immune responses. When a pathogen is detected, information is communicated to T cells through antigen presentation.

Following activation, naive CD4+ T cells differentiate into one of several lineages of T helper cells (Th1, Th2, Th9, Th17, or Th22), depending primarily on the antigen, the strength of the TCR signal, and the cytokines present in the surrounding extracellular environment. Differentiation of each T cell subset is associated with the expression of specific transcription factors followed by secretion of a defined array of cytokines that orchestrate a directed response to the antigen. The actions of T helper cells are balanced by regulatory T (Treg) cells, a subpopulation that specializes in suppression of T cell-mediated immune responses. Failure to activate an appropriate T cell response can lead to chronic infection, while exaggerated T cell responses can cause excessive tissue damage and are associated with inflammatory and autoimmune diseases.

Primary CD4+ Helper T Cells (ATCC® PCS-800-016™)

Human Th1 Cell Differentiation Kit
Differentiates naïve CD4+ lymphocytes into mature Th1 effector cells.

Mouse Th1 Cell Differentiation Kit New!
Differentiates naïve CD4+ mouse lymphocytes into Th1-polarized effector cells.

Human Th2 Cell Differentiation Kit
Differentiates naïve CD4+ lymphocytes into mature Th2 effector cells.

Mouse Th2 Cell Differentiation Kit New!
Differentiates naïve CD4+ mouse lymphocytes into Th2-polarized effector cells.

Human Th17 Cell Differentiation Kit
Differentiates naïve CD4+ lymphocytes into mature Th17 effector cells.

Mouse Th17 Cell Differentiation Kit New!
Differentiates naïve CD4+ mouse lymphocytes into Th17-polarized effector cells.

Human Treg Cell Differentiation Kit
Differentiates naïve CD4+ human lymphocytes into CD25+FoxP3+ regulatory T cells.

Mouse Treg Cell Differentiation Kit
Differentiates naïve CD4+ mouse lymphocytes into CD25+FoxP3+ regulatory T cells.