Caspase-Glo 6 Assay, 10ml Item ID: PMG0970

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Caspase-Glo 6 Assay is a homogeneous, luminescent assay that measures caspase-6 activity.

The Caspase-Glo 6 Assay is a homogeneous, luminescent assay that measures caspase-6 activity. Caspase-6 is a member of the cysteine aspartic acid-specific protease family and has a key effector role in the cleavage of specific target proteins during apoptosis. The Caspase-Glo 6 Assay provides a luminogenic substrate, Z-VEID-aminoluciferin, in a buffer optimized for caspase-6 and luciferase activity. The addition of a single Caspase-Glo 6 Reagent in an add-mix-measure format results in cleavage of the substrate, releasing aminoluciferin, and generation of a glow-type luminescent signal in the presence of Ultra-Glo Recombinant Luciferase. The luminescent signal is proportional to the amount of caspase-6 activity present. The homogeneous Caspase-Glo 6 Assay is designed for use with purified enzyme preparations in multiwell plate formats, making it ideal for automated high-throughput screening for caspase-6 activity and inhibitors of caspase-6 activity. Caspase-6 cleavage of the luminogenic substrate containing the VEID consensus sequence.