MET Genetic Alteration Cell Line Panel Item ID: ATCTCP1036
| Permits and Restrictions |
View Permits |
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| Organism | Homo sapiens, human |
| Components | ATCC CRL-5973 SNU-5ATCC HTB-135 Hs 746TATCC CRL-1585 C32ATCC CRL-2351 AU565ATCC CRL-5822 NCI-N87 |
| Applications | This validated panel is composed of 5 select human tumor cell lines carrying various degrees of MET gene copy number changes, and is useful for RAS pathway research and for anti-cancer drug discovery. |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments |
MET is a member of the tyrosine kinase receptor family, which leads signal transduction from the extracellular matrix into the cytoplasm after binding its ligang, hepatocyte growth factor (HGF). The MET/HGF signaling pathway has been reported to be aberrantly activated in many human cancers, e.g., gastric cancer. In addition, amplification of MET correlates with poor prognosis, and plays a role in acquired resistance to EGFR inhibitors in patients with EGFR-mutant tumors. The MET Genetic Alteration Cell Panel (ATCC TCP-1036) is composed of five human tumor cells that carry various degrees of MET gene copy number changes. The MET status of each cell line has been validated by ATCC. This panel is useful for studying bio-functions of MET and MET amplification, as well as tyrosine kinase inhibitor anti-cancer drug discovery. |
| Product Format | 5 cryopreserved cell lines |
| Storage Conditions | liquid nitrogen vapor phase (less than -130°C) only |
| Permits |
These permits may be required for shipping this product to Australia:
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| Basic Documentation | Product Sheet Certificate of Analysis SDS |
| Other Documentation | Recommended Culture Conditions Genetic Alteration Panels - Brochure |