ERK Genetic Alteration Cell Line Panel Item ID: ATCTCP1033
| Permits and Restrictions |
View Permits |
|---|---|
| Organism | Homo sapiens, human |
| Components |
ATCC CRL-2577 RKOATCC CRL-9446 CHL-1ATCC HTB-111 AN3 CAATCC HTB-2 RT4ATCC HTB-20 BT-474ATCC HTB-65 MeWoATCC HTB-9 5637 |
| Applications | This validated panel is composed of 7 select human tumor cell lines carrying MAPK3 and MAPK1 gene mutations, and is useful for ERK pathway research and for anti-cancer drug discovery. |
| Biosafety Level |
1
Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country. |
| Comments | ERK1 and ERK2 are important members of the mitogen-activated protein kinases (MAPKs) family, which controls a broad range of cellular activities and physiological processes, such as proliferation, cell survival, migration, morphology determination and oncogenic transformation. The MAPK1 gene encodes the ERK2 protein, and the MAPK3 gene encodes the ERK1 protein. ERK1/2 can be activated by upstream RAS-RAF-MEK signaling. Elevated and constitutive activation of ERK1/2 has been detected in various common cancer types. Mutations in the MAPK3 and MAPK1 genes have be observed in a subset of human tumors by next generation sequencing. The ERK genetic alteration cell panel (ATCC TCP-1033) is composed of 7 selected human tumor cell lines from various common cancer types that carry COSMIC database validated mutations within MAPK1 and MAPK3 genes. This panel of cell lines also encompasses various basal levels of phosphor-ERK1/2. The MAPK1 and MAPK3 gene alteration status of each cell line has been sequenced and validated by ATCC. |
| Product Format | 7 cryopreserved cell lines |
| Storage Conditions | liquid nitrogen vapor phase (less than -130°C) only |
| Permits |
These permits may be required for shipping this product to Australia:
|
|---|---|
| Basic Documentation | Product Sheet Certificate of Analysis SDS |
| Other Documentation | Recommended Culture Conditions Genetic Alteration Panels - Brochure |