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Scientists at the University of Oxford have described a new twist on cancer immunotherapy, combining two independent cell killing approaches in a single therapeutic with high potency and broad applicability. By inserting a gene for a bispecific T cell engager (BiTE) within the EnAdenotucirev genome, Seymore et al were able to drive direct oncolysis and T cell mediated killing of EpCAM expressing tumour cells with high efficiency.

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