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The University of Pennslyvania has produced a great publication about improving the efficacy of adoptive T-Cell therapy in solid tumours by using 3rd generation CAR-T cells:

Gruden et al from University of Pennslyvania show that CD4+ and CD8+ T cells exhibit distinct persistence and effector phenotypes, depending on the identity of specific intracellular signalling domains (ICDs). Those CARs with ICOS and 4-1BB ICDs demonstrated an increased efficacy in solid tumours.

The xCELLigence Real-Time Cell Analsysis (RTCA) system from ACEA Bioscience was used to evaluate the lysis of non–small cell lung L55 tumour cells when treated with CAR T cells over a 20-hour period. Learn More about the advantages of using RTCA for CAR-T