Questions? Feedback? powered by Olark live chat software
All Site

Cells b cells smallB lymphocytes (B cells) are an essential component of the humoral immune response. Produced in the bone marrow, B cells migrate to the spleen and other secondary lymphoid tissues where they mature and differentiate into immunocompetent B cells. Part of the adaptive immune system, B cells are responsible for generating antibodies to specific antigens, which they bind via B cell receptors (BCR).

Activation of B cells occurs via antigen recognition by BCRs and a required co-stimulatory, secondary activation signal provided by either helper T cells or the antigen itself. This results in stimulation of B cell proliferation and the formation of germinal centers where B cells differentiate into plasma cells or memory B cells. Importantly, all B cells derived from a specific progenitor B cell are clones that recognize the same antigen epitope.

Plasma cells are found in the spleen and lymph nodes and are responsible for secreting different classes of clonally unique antibodies that are found in the blood. Following the primary response, a small number of B cells develop into memory B cells, which express high-affinity surface immunoglobulins (mainly IgG), survive for a longer period of time, and enable a rapid secondary response.

ATCC logo
Primary CD19+ B Cells (ATCC® PCS-800-018™)

Resources for in vitro Differentiation and Expansion:

B Cells

Molecule

Species

Source

Catalog #

 

BAFF/Blys/TNFSF13B

Human

CHO

7537-BF

 

 

Human

NS0

2149-BF

 

 

Mouse

NS0

8876-BF

 

CD40 Ligand/TNFSF5

Human

HEK293

6420-CL

 

 

Human

E. coli

2706-CL

 

 

Human

E. coli

6245-CL

 

 

Mouse

CHO

8230-CL

 

 

Rat

CHO

8414-CL

 

IFN-g

Human

E. coli

285-IF

 

 

Human

HEK293

10067-IF

 

 

Mouse

E. coli

485-MI

 

 

Rat

E. coli

585-IF

 

IL-2

Human

E. coli

202-IL

 

 

Mouse

E. coli

402-ML

 

 

Rat

E. coli

502-RL

 

IL-4

Human

E. coli

204-IL

 

 

Human

CHO

6507-IL

 

 

Mouse

E. coli

404-ML

 

 

Rat

E. coli

504-RL

 

IL-10

Human

Sf21 (baculovirus)

217-IL

 

 

Human

Sf21 (stably transfected)

217-ILB

 

 

Human

E. coli

1064-IL

 

 

Mouse

E. coli

417-ML

 

 

Rat

E. coli

522-RLB

 

IL-21

Human

E. coli

8879-IL

 

 

Mouse

E. coli

594-ML

 

Cell Resource

Click on the images below to find out more about other immune cell types.

Macrophage cellNeutrophil cellRegulatory T CellCytotoxic T CellNatural killer CellDendritic cell

B CellHelper T CellMyleoid Derived CellMemory T Cell